Destination Medical Center in Rochester, Minn., is a 20-year economic development initiative that, at $5.6 billion, is the largest in Minnesota’s history. The Mayo Clinic will account for $3.5 billion of that investment, with the state kicking in $585 million and private investors $2.1 billion.

Among this initiative’s six sub districts will be an urban research campus called Discovery Square, a 16-block mixed-use neighborhood for entrepreneurs, researchers, startups, and established businesses with Mayo Clinic adding more than 2 million sf of collaborative space.